Tuesday, October 9, 2007

Comments on specific drug classes used in management of lipid disorders in persons with diabetes

Statins are first-line therapy for reducing LDL cholesterol levels in persons with diabetes and they are generally well tolerated. They have the advantage of lowering VLDL cholesterol as well as LDL cholesterol; thus they can assist in attaining the non-HDL-cholesterol goal when triglyceride levels are ¡Ý200 mg/dL. Bile acid sequestrants also are effective LDL-lowering drugs in persons with diabetes. Their potential utility for LDL lowering either as monotherapy or in combination with statins should not be overlooked. They generally are not contraindicated simply because of their tendency to raise triglycerides. Nonetheless, triglyceride levels should be monitored. Fibrates favorably modify diabetic dyslipidemia. They are well tolerated, and do not worsen hyperglyc View the rest of this article

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